Dr. Mario Express features the general gameplay of earlier Dr. Mario puzzle games, which focus on eliminating colored viruses from the playing field by matching them with colored capsules. Dr. Mario Express received generally positive reviews, but was criticized for offering fewer playable game modes than earlier Dr. Mario titles.

Dr. Mario Express features the general gameplay of earlier Dr. Mario puzzle games, which focus on eliminating colored viruses from the playing field by matching them with colored capsules. Dr. Mario Express received generally positive reviews, but was criticized for offering fewer playable game modes than earlier Dr. Mario titles.