Mighty Guy combines the overhead perspective of a run and gun with the gameplay of a beat 'em up. Your character has to fight their way through a desert, town, and mechanical area filled with machines, humans, and bugs to fight. You use punches or a jump kick to defeat enemies as you advance upward. Some enemies will drop guns that you can pick up to use for yourself, making the game play more like a conventional run and gun. Once you defeat the boss at the end, the game will loop back to the beginning and repeat until you run out of lives.

Mighty Guy combines the overhead perspective of a run and gun with the gameplay of a beat 'em up. Your character has to fight their way through a desert, town, and mechanical area filled with machines, humans, and bugs to fight. You use punches or a jump kick to defeat enemies as you advance upward. Some enemies will drop guns that you can pick up to use for yourself, making the game play more like a conventional run and gun. Once you defeat the boss at the end, the game will loop back to the beginning and repeat until you run out of lives.