Something mysterious is going on at the reploid research island. The reploids have ceased functionality... their data strangely erased. Now the investigation team encounters "irregular" reploids infected with a strange new DNA chip. This strange DNA chip, known as "DNA Soul", replaces useful data with a devastating Sigma virus and places all reploids in imminent danger. Now, it's up to Mega Man X and his comrade, Zero, to get to the damaged island and find out who is behind the DNA Soul virus.

Something mysterious is going on at the reploid research island. The reploids have ceased functionality... their data strangely erased. Now the investigation team encounters "irregular" reploids infected with a strange new DNA chip. This strange DNA chip, known as "DNA Soul", replaces useful data with a devastating Sigma virus and places all reploids in imminent danger. Now, it's up to Mega Man X and his comrade, Zero, to get to the damaged island and find out who is behind the DNA Soul virus.