Crash Twinsanity is the fifth mainline series game of the Crash Bandicoot series where Crash and the villain Cortex are forced into partnership. Each character occupies the same screen but they run along on different planes. Crash's gameplay is mostly the same as before, he can still do his trademark spin attack, double jump and body slam moves. The originality comes in his duo with Dr. Cortex, as he can throw him to places he can't reach himself or use him as a hammer to slap enemies. The consistent conflict between both heroes causes many funny situations.

Crash Twinsanity is the fifth mainline series game of the Crash Bandicoot series where Crash and the villain Cortex are forced into partnership. Each character occupies the same screen but they run along on different planes. Crash's gameplay is mostly the same as before, he can still do his trademark spin attack, double jump and body slam moves. The originality comes in his duo with Dr. Cortex, as he can throw him to places he can't reach himself or use him as a hammer to slap enemies. The consistent conflict between both heroes causes many funny situations.